Angiotensin II (AngII), as an octapeptide hormone normally ionized at physiological pH,
cannot cross cell membranes and thus, relies on, two (mainly) G protein-coupled receptor …

Diabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives
maladaptive structural changes and functional damage to the vasculature. Attenuation of this …

Bone regulates its mass and quality in response to diverse mechanical, hormonal, and local
signals. The bone anabolic or catabolic responses to these signals are often received by …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac
arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of …

Myocardial infarction and revascularization cause cardiac ischemia/reperfusion (I/R) injury
featuring cardiomyocyte death and inflammation. The Ca 2+/calmodulin dependent protein …

Chagas cardiomyopathy caused by infection with the intracellular parasite Trypanosoma
cruzi is the most common and severe expression of human Chagas disease. Heart failure …

Inherited cardiac arrhythmias are a group of genetic diseases predisposing to sudden
cardiac arrest, mainly resulting from variants in genes encoding cardiac ion channels or …

Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a ubiquitous
mediator of cellular Ca 2+ signals with both enzymatic and structural functions. Here, we …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of Ca2+-
dependent signaling pathways in various cell types throughout the body. Its neuronal …

Widespread application of the typical phthalate plasticizers, di (2-ethylhexyl) phthalate
(DEHP), poses a serious potential threat to the health of animals and even humans …