Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology
Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …
physical object (eg, planes and human organs), predict the behavior of the object, and …
Opportunities for improving brain cancer treatment outcomes through imaging-based mathematical modeling of the delivery of radiotherapy and immunotherapy
Immunotherapy has become a fourth pillar in the treatment of brain tumors and, when
combined with radiation therapy, may improve patient outcomes and reduce the …
combined with radiation therapy, may improve patient outcomes and reduce the …
The hallmarks of mathematical oncology
JA Bull, HM Byrne - Proceedings of the IEEE, 2022 - ieeexplore.ieee.org
Over the past 25 years, there has been an unparalleled increase in understanding of cancer
biology. This transformation is exemplified by Hanahan and Weinberg's decision in 2011 to …
biology. This transformation is exemplified by Hanahan and Weinberg's decision in 2011 to …
[HTML][HTML] Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system
Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …
Traditionally tumor response was hypothesized to be due to high levels of cell death …
Mathematical modelling of the dynamics of image-informed tumor habitats in a murine model of glioma
Tumors exhibit high molecular, phenotypic, and physiological heterogeneity. In this effort, we
employ quantitative magnetic resonance imaging (MRI) data to capture this heterogeneity …
employ quantitative magnetic resonance imaging (MRI) data to capture this heterogeneity …
A practical guide for the generation of model-based virtual clinical trials
Mathematical modeling has made significant contributions to drug design, development, and
optimization. Virtual clinical trials that integrate mathematical models to explore patient …
optimization. Virtual clinical trials that integrate mathematical models to explore patient …
Modelling glioma progression, mass effect and intracranial pressure in patient anatomy
Increased intracranial pressure is the source of most critical symptoms in patients with
glioma, and often the main cause of death. Clinical interventions could benefit from non …
glioma, and often the main cause of death. Clinical interventions could benefit from non …
[HTML][HTML] A data assimilation framework to predict the response of glioma cells to radiation
J Liu, DA Hormuth, J Yang… - … and engineering: MBE, 2023 - ncbi.nlm.nih.gov
We incorporate a practical data assimilation methodology into our previously established
experimental-computational framework to predict the heterogeneous response of glioma …
experimental-computational framework to predict the heterogeneous response of glioma …
[HTML][HTML] Adaptive therapy for ovarian cancer: An integrated approach to PARP inhibitor scheduling
Toxicity and emerging drug resistance are important challenges in PARP inhibitor (PARPi)
treatment of ovarian cancer. Recent research has shown that evolutionary-inspired …
treatment of ovarian cancer. Recent research has shown that evolutionary-inspired …
A Multi-Compartment Model of Glioma Response to Fractionated Radiation Therapy Parameterized via Time-Resolved Microscopy Data
Purpose Conventional radiobiology models, including the linear-quadratic model, do not
explicitly account for the temporal effects of radiation, thereby making it difficult to make time …
explicitly account for the temporal effects of radiation, thereby making it difficult to make time …