Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

PB Gilbert, DC Montefiori, AB McDermott, Y Fong… - Science, 2022 - science.org
In the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed
for neutralizing and binding antibodies as correlates of risk for COVID-19 disease and as …

[HTML][HTML] Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape

JS Tregoning, KE Flight, SL Higham, Z Wang… - Nature reviews …, 2021 - nature.com
Where 2020 saw the development and testing of vaccines against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has …

Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis

ARYB Lee, SY Wong, LYA Chai, SC Lee, MX Lee… - Bmj, 2022 - bmj.com
Objective To compare the efficacy of covid-19 vaccines between immunocompromised and
immunocompetent people. Design Systematic review and meta-analysis. Data sources …

[HTML][HTML] Randomized trial of a third dose of mRNA-1273 vaccine in transplant recipients

VG Hall, VH Ferreira, T Ku, M Ierullo… - … England Journal of …, 2021 - Mass Medical Soc
A Third Vaccine Dose in Organ-Transplant Recipients It is known that people receiving
immune suppressive therapy, such as recipients of solid-organ transplants, have a …

[HTML][HTML] Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review

T Fiolet, Y Kherabi, CJ MacDonald, J Ghosn… - Clinical Microbiology …, 2022 - Elsevier
Background Vaccines are critical cost-effective tools to control the coronavirus disease 2019
(COVID-19) pandemic. However, the emergence of variants of the severe acute respiratory …

[HTML][HTML] Comparative effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) vaccines in preventing COVID-19 hospitalizations among adults …

WH Self - MMWR. Morbidity and mortality weekly report, 2021 - cdc.gov
Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson)
Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocompromising …

[PDF][PDF] Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

S Afkhami, MR D'Agostino, A Zhang, HD Stacey… - Cell, 2022 - cell.com
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …

[HTML][HTML] Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

F Muecksch, Z Wang, A Cho, C Gaebler, T Ben Tanfous… - Nature, 2022 - nature.com
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent
individuals,–. Despite the reduced protection from infection, individuals who received three …

[HTML][HTML] SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

S Cele, L Jackson, DS Khoury, K Khan, T Moyo-Gwete… - MedRxiv, 2021 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 Omicron, first identified in Botswana and South Africa, may
compromise vaccine effectiveness and the ability of antibodies triggered by previous …

[HTML][HTML] SARS-CoV-2 variants, vaccines, and host immunity

P Mistry, F Barmania, J Mellet, K Peta… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus
that emerged at the end of 2019 in the Hubei province of China. SARS-CoV-2 causes …