Therapeutic role of tocilizumab in SARS-CoV-2-induced cytokine storm: rationale and current evidence

C Pelaia, C Calabrese, E Garofalo, A Bruni… - International Journal of …, 2021 - mdpi.com
Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the
worst possible scenarios is represented by the critical lung damage caused by the severe …

Mediterranean diet for the prevention of gestational diabetes in the Covid-19 era: implications of Il-6 in diabesity

AL Fedullo, A Schiattarella, M Morlando… - International journal of …, 2021 - mdpi.com
The aim of this review is to highlight the influence of the Mediterranean Diet (MedDiet) on
Gestational Diabetes Mellitus (GDM) and Gestational Weight Gain (GWG) during the COVID …

Prevalence of micronutrient deficiencies in patients hospitalized with COVID-19: an observational cohort study

M Voelkle, C Gregoriano, P Neyer, D Koch, A Kutz… - Nutrients, 2022 - mdpi.com
Background: A higher risk for severe clinical courses of coronavirus disease 2019 (COVID-
19) has been linked to deficiencies of several micronutrients. We therefore studied the …

Post-acute COVID-19 joint pain and new onset of rheumatic musculoskeletal diseases: a systematic review

J Ciaffi, E Vanni, L Mancarella, V Brusi, L Lisi, F Pignatti… - Diagnostics, 2023 - mdpi.com
As the number of reports of post-acute COVID-19 musculoskeletal manifestations is rapidly
rising, it is important to summarize the current available literature in order to shed light on …

[HTML][HTML] Interleukin-6 (IL-6) inhibitors as therapeutic agents for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

RT Pinzon, VO Wijaya, RB Buana - Journal of infection and public health, 2021 - Elsevier
Introduction Preliminary studies showed that coronavirus disease 2019 (COVID-19) disrupts
body immune system, including dysregulation of cytokine interleukin-6 (IL-6). IL-6 inhibitors …

Efficacy of tocilizumab in the treatment of COVID‐19: An umbrella review

MM Rezaei Tolzali, M Noori, P Shokri… - Reviews in Medical …, 2022 - Wiley Online Library
Tocilizumab is an interleukin (IL)‐6 receptor inhibitor that has been proposed as a
therapeutic agent for treating coronavirus disease 2019 (COVID‐19). The aim of this …

Sarilumab administration in COVID-19 patients: Literature review and considerations

A Marino, A Munafò, E Augello, CM Bellanca… - Infectious Disease …, 2022 - mdpi.com
Two years have passed since WHO declared a pandemic state for SARS-CoV-2 infection.
COVID-19 pathogenesis consists of a first viral phase responsible for early symptoms …

Expanding the spectrum of the hyperferritinemic syndrome, from pathogenic mechanisms to clinical observations, and therapeutic implications

P Ruscitti, I Di Cola, C Di Muzio, N Italiano, F Ursini… - Autoimmunity …, 2022 - Elsevier
From the introduction of hyperferritinemic syndrome concept, a growing body of evidence
has suggested the role of ferritin as a pathogenic mediator and a relevant clinical feature in …

Cytokine drizzle—the rationale for abandoning “cytokine storm”

AE Stolarski, J Kim, Q Zhang, DG Remick - Shock, 2021 - journals.lww.com
Background:“Cytokine storm” has been used to implicate increased cytokine levels in the
pathogenesis of serious clinical conditions. Similarities with Severe Acute Respiratory …

Disruptions in hypothalamic–pituitary–gonadal Axis development and their IgG modulation after prenatal systemic inflammation in male rats

V Ignatiuk, M Izvolskaia, V Sharova… - International Journal of …, 2023 - mdpi.com
The development of the neuroendocrine system, including the hypothalamic–pituitary–
gonadal (HPG) axis, is sensitive to environmental impacts during critical developmental …