Advances and gaps in SARS-CoV-2 infection models

C Muñoz-Fontela, L Widerspick, RA Albrecht… - PLoS …, 2022 - journals.plos.org
The global response to Coronavirus Disease 2019 (COVID-19) is now facing new
challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern …

Biological properties of SARS-CoV-2 variants: epidemiological impact and clinical consequences

R Hoteit, HM Yassine - Vaccines, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to
the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May …

Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters

K McMahan, V Giffin, LH Tostanoski, B Chung… - Med, 2022 - cell.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
(B. 1.1. 529) variant has proven to be highly transmissible and has outcompeted the Delta …

Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA. 5 in male Syrian hamsters

RRG Machado, JL Walker, D Scharton… - Nature …, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron subvariant BA. 5 rapidly spread worldwide and replaced
BA. 1/BA. 2 in many countries, becoming globally dominant. BA. 5 has unique amino acid …

Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission

S Horiuchi, K Oishi, L Carrau, J Frere, R Møller… - Science …, 2021 - science.org
SARS-CoV-2 has caused morbidity and mortality across the globe. As the virus spreads,
new variants are arising that show enhanced capacity to bypass preexisting immunity. To …

ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

N van Doremalen, JE Schulz, DR Adney… - Nature …, 2022 - nature.com
Abstract ChAdOx1 nCoV-19 (AZD1222) is a replication-deficient simian adenovirus–
vectored vaccine encoding the spike (S) protein of SARS-CoV-2, based on the first …

Updated vaccine protects against SARS-CoV-2 variants including Omicron (B. 1.1. 529) and prevents transmission in hamsters

S Sharma, T Vercruysse, L Sanchez-Felipe… - Nature …, 2022 - nature.com
Current COVID-19 vaccines are based on prototypic spike sequences from ancestral 2019
SARS-CoV-2 strains. However, the ongoing pandemic is fueled by variants of concern …

Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern

S Mohandas, PD Yadav, G Sapkal, AM Shete… - …, 2022 - thelancet.com
Summary Background SARS-CoV-2 Omicron variant is rampantly spreading across the
globe. We assessed the pathogenicity and immune response generated by BA. 1.1 sub …

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

J Logue, RM Johnson, N Patel, B Zhou… - Nature …, 2023 - nature.com
SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …

MVA-CoV2-S vaccine candidate neutralizes distinct variants of concern and protects against SARS-CoV-2 infection in hamsters

R Boudewijns, P Pérez, A Lázaro-Frías… - Frontiers in …, 2022 - frontiersin.org
To control the coronavirus disease 2019 (COVID-19) pandemic and the emergence of
different variants of concern (VoCs), novel vaccines against severe acute respiratory …