For the past two decades, hematopoietic cell transplantation (HCT) has been used as
effective therapy for selected inherited metabolic diseases (IMD) including Hurler (MPS IH) …

Abstract Felix R, Hofstetter W, Cecchini MG. Recent developments in the understanding of
the pathophysiology of osteopetrosis. Eur J Endocrinol 1996; 134: 143–56. ISSN 0804 …

Osteoblast development is a complex process involving the expression of specific growth
factors and regulatory proteins that control cell proliferation, differentiation, and maturation …

Together, osteoporosis and osteopetrosis comprise a substantial proportion of the bone
diseases that severely affect humans. In order to understand and effectively treat these …

Abstract Osteopetrosis or Albers-Schonberg disease is a rare hereditary disorder of
osteoclast function in which resorption of bone is diminished, resulting in abnormally dense …

The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat
first mandibular molar, a decrease in the expression of osteoprotegerin (OPG) in the dental …

Osteopetrosis is a heterogeneous group of bone diseases characterized by an excess
accumulation of bone and a variety of immune defects. Osteopetrosis (op) and incisors …

Osteoactivin (OA) is more highly expressed in the bones of osteopetrotic mutant rats (op/op)
than in those of their normal littermates and is the homologue of human nmb, a cDNA more …

Bone mineral density (BMD) and mechanical strength generally show strong positive
correlations. However, osteopetrosis is a metabolic bone disease with increased skeletal …

It has recently been shown that following treatment with colony-stimulating factor-1 (CSF-1)
the osteopetrotic condition in toothless (tl) rats greatly improves and growth is accelerated …