Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …

Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

Oncogene-induced replication stress generates endogenous DNA damage that activates
cGAS–STING-mediated signalling and tumour suppression,–. However, the precise …

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

Several aspects of telomere biology are regulated by the telomeric repeat-containing RNA
TERRA. While TERRA expression is conserved through evolution, species-specific …

Mitochondria are versatile organelles and essential components of numerous biological
processes such as energy metabolism, signal transduction, and cell fate determination. In …

Innate immunity is not only the first line of host defense against microbial infections but is
also crucial for the host responses against a variety of noxious stimuli. Z-DNA binding …