Modeling and simulation of drug disposition has emerged as an important tool in drug
development, clinical study design and regulatory review, and the number of physiologically …

Over the years, significant progress has been made in reducing metabolic instability due to
cytochrome P450-mediated oxidation. High-throughput metabolic stability screening has …

Investigation of the pharmacokinetics (PK) of a compound is of significant importance during
the early stages of drug development, and therefore several in vitro systems are routinely …

In this work, we first describe the population variability in hepatic drug metabolism using
cryopreserved hepatocytes from five different donors cultured in a perfused three …

Early prediction of human clearance is often challenging, in particular for the growing
number of low-clearance compounds. Long-term in vitro models have been developed …

Organic anion–transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 transporters
play an important role in hepatic drug disposition. Recently, an increasing number of studies …

Purpose Develop a minimal mechanistic model based on in vitro–in vivo extrapolation
(IVIVE) principles to predict extent of passive tubular reabsorption. Assess the ability of the …

The programme for the 2015 AAPS Annual Meeting and Exhibition (Orlando, FL; 25–29
October 2015) included a sunrise session presenting an overview of the state-of-the-art tools …

The greater utilization and acceptance of physiologically‐based pharmacokinetic (PBPK)
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …

In recent years, the functional interplay between drug-metabolizing enzymes (DMEs) and
drug transporters (DTs) in drug absorption and disposition, as well as the complex drug …