Chromatin is organized into multiscale three-dimensional structures, including chromosome
territories, A/B compartments, topologically associating domains, and chromatin loops. This …

Global climate change has broad-ranging impacts on the natural environment and human
civilization. Increasing average temperatures along with more frequent heat waves …

Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness–. Constructing complete fitness landscapes, in which DNA …

Abstract Genome-Wide Association Studies (GWAS) have elucidated the genetic
components of Parkinson's Disease (PD). However, because the vast majority of GWAS …

The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new …

Biological plasticity is ubiquitous. How does the brain navigate this complex plasticity space,
where any component can seemingly change, in adapting to an ever-changing …

Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Emerging brain-inspired neuromorphic computing paradigms require devices that can
emulate the complete functionality of biological synapses upon different neuronal activities …

The mechanistic tie between genome-wide association study (GWAS)-implicated risk
variants and disease-relevant cellular phenotypes remains largely unknown. Here, using …

Noncoding RNAs (ncRNAs) represent the majority of the transcriptome and play important
roles in regulating neuronal functions. ncRNAs are exceptionally diverse in both structure …