Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction
upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT …

Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ)
are the major downstream effectors of the Hippo pathway, which regulates tissue …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

Mesenchymal stem cells (MSCs) are multipotent cells that represent a promising source for
regenerative medicine. MSCs are capable of osteogenic, chondrogenic, adipogenic and …

The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized
by excessive synthesis, remodeling, and contraction of extracellular matrix produced by …

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …