Massively parallel DNA sequencing technologies provide an unprecedented ability to
screen entire genomes for genetic changes associated with tumour progression. Here we …

Improved knowledge of all aspects of adipose biology will be required to counter the
burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the …

Wnt growth factors are fundamental regulators of cell fate, but how the Wnt signal is
translated into biological responses is incompletely understood. Here, we report that TAZ, a …

The Hippo pathway senses cell density information to control tissue growth by regulating the
localization of the transcriptional regulators TAZ and YAP (TAZ/YAP). TAZ/YAP also regulate …

YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …

The development of obesity not only depends on the balance between food intake and
caloric utilization but also on the balance between white adipose tissue, which is the primary …

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional
co-activator proteins that play key roles in many diverse biological processes, ranging from …

The Hippo signaling pathway was initially defined by genetic studies in Drosophila to
regulate tissue growth and organ size [1, 2]. This pathway is highly conserved in mammals …

Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth,
differentiation, function, and death. Considerable progress has been made in our …

Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …