Hippo pathway-independent restriction of TAZ and YAP by angiomotin
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by
phosphorylating them for cytoplasmic sequestration or degradation. In this report, we …
phosphorylating them for cytoplasmic sequestration or degradation. In this report, we …
Composite nanocoatings of biomedical magnesium alloy implants: advantages, mechanisms, and design strategies
D Li, D Dai, G Xiong, S Lan, C Zhang - Advanced Science, 2023 - Wiley Online Library
The rapid degradation of magnesium (Mg) alloy implants erodes mechanical performance
and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among …
and interfacial bioactivity, thereby limiting their clinical utility. Surface modification is among …
Nuclear receptors and their selective pharmacologic modulators
Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …
Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation
Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation
must be regulated for applications in regenerative medicine. Stem cells are surrounded by …
must be regulated for applications in regenerative medicine. Stem cells are surrounded by …
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
Abstract TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif,
modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role …
modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role …
Expression of α-smooth muscle actin determines the fate of mesenchymal stromal cells
Pro-fibrotic microenvironments of scars and tumors characterized by increased stiffness
stimulate mesenchymal stromal cells (MSCs) to express α-smooth muscle actin (α-SMA). We …
stimulate mesenchymal stromal cells (MSCs) to express α-smooth muscle actin (α-SMA). We …
The hippo pathway in heart development, regeneration, and diseases
Q Zhou, L Li, B Zhao, KL Guan - Circulation research, 2015 - Am Heart Assoc
The heart is the first organ formed during mammalian development. A properly sized and
functional heart is vital throughout the entire lifespan. Loss of cardiomyocytes because of …
functional heart is vital throughout the entire lifespan. Loss of cardiomyocytes because of …
Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65
EM Morin-Kensicki, BN Boone, M Howell… - … and cellular biology, 2006 - Taylor & Francis
YAP is a multifunctional adapter protein and transcriptional coactivator with several binding
partners well described in vitro and in cell culture. To explore in vivo requirements for YAP …
partners well described in vitro and in cell culture. To explore in vivo requirements for YAP …
[HTML][HTML] Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts
Bone is a dynamic tissue that is constantly renewed by the coordinated action of two cell
types, ie., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in …
types, ie., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in …
Roles of non-canonical Wnt signalling pathways in bone biology
J Lojk, J Marc - International journal of molecular sciences, 2021 - mdpi.com
The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …