Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage,
bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays …

Since its discovery, the Hippo pathway has emerged as a central signaling network in
mammalian cells. Canonical signaling through the Hippo pathway core components …

Pluripotent mesenchymal stem cells (MSCs) are bone marrow stromal progenitor cells that
can differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages …

The relationship between bone and fat formation within the bone marrow microenvironment
is complex and remains an area of active investigation. Classical in vitro and in vivo studies …

The recent development of molecular biology and mouse genetics and the analysis of the
skeletal phenotype induced by genetic mutations in humans led to a better understanding of …

In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct
skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which …

Bone is one of the most dynamic organs in the body that continuously undergoes
remodeling through bone formation and resorption. A cascade of molecules and pathways …

Growth factors and mechanical cues synergistically affect cellular functions, triggering a
variety of signaling pathways. The molecular levels of such cooperative interactions are not …

Neural crest cells (NCCs) are multipotent stem cells that can differentiate into multiple cell
types, including the osteoblasts and chondrocytes, and constitute most of the craniofacial …

Cells in the body reside within the extracellular matrix (ECM), a three-dimensional
environment that not only provides structural support for the cells, but also influences cellular …