Breast cancer is a common malignancy among women worldwide. Regardless of the
economic status of a country, breast cancer poses a burden in prevention, diagnosis and …

Inhibition of poly (ADP-ribose) polymerase (PARP) activity induces synthetic lethality in
mutated BRCA1/2 cancers by selectively targeting tumor cells that fail to repair DNA double …

Immune checkpoint blockade (ICB) is a powerful approach for cancer therapy although good
responses are only observed in a fraction of cancer patients. Breast cancers caused by …

Abstract Development of novel strategies to overcome chemoresistance is central goal in
ovarian cancer research. Natural history of the cancer development and progression is …

Background Co-expression correlations provide the ability to predict gene functionality
within specific biological contexts, such as different tissue and disease conditions. However …

Approximately 5–10% of all breast cancer (BC) cases are caused by germline pathogenic
variants (GPVs) in various cancer predisposition genes (CPGs). The most common …

Introduction BRCA gene mutations are associated with hereditary ovarian cancer. BRCA
plays a key role in genome integrity, and mutations result in an increased risk for ovarian …

Ovarian cancers remain one of the most common causes of gynecologic cancer-related
death in women worldwide. The standard treatment comprises platinum-based …

Breast and ovarian cancer represent two of the most common tumor types in females
worldwide. Over the years, several non‑modifiable and modifiable risk factors have been …

The Sae2/CtIP protein is required for efficient processing of DNA double-strand breaks that
initiate homologous recombination in eukaryotic cells. Sae2/CtIP is also important for …