It is widely acknowledged that infectious diseases have wrought immense havoc on human
society, being regarded as adversaries from which humanity cannot elude. In recent years …

Single-cell technologies have transformed biomedical research over the last decade,
opening up new possibilities for understanding cellular heterogeneity, both at the genomic …

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …

Conventional methods fall short in unraveling the dynamics of rare cell types related to
aging and diseases. Here we introduce EasySci, an advanced single-cell combinatorial …

The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the
brain is a highly interconnected integrative hub for sensory and spatial information; it also …

Fibroblasts are important regulators of inflammation, but whether fibroblasts change
phenotype during resolution of inflammation is not clear. Here we use positron emission …

Midbrain dopamine (mDA) neurons comprise diverse cells with unique innervation targets
and functions. This is illustrated by the selective sensitivity of mDA neurons of the substantia …

The pathogenesis of Alzheimer's disease (AD) depends on environmental and heritable
factors, with remarkable differences evident between individuals at the molecular level. Here …

Legumes establish a symbiotic relationship with nitrogen-fixing rhizobia by developing
nodules. Nodules are modified lateral roots that undergo changes in their cellular …

Background Mouse models have been widely used to understand kidney disease
pathomechanisms and play an important role in drug discovery. However, these models …