Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …

Neurological disorders (NDs) are one of the leading causes of global death. A sustained
neuroinflammatory response has been reported to be associated with the pathogenesis of …

Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur
concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in …

The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …

Cognitive impairment is a multifactorial and multi-step pathological process that places a
heavy burden on patients and the society. Neuroinflammation is one of the main factors …

Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive dysfunction and behavioral impairment. The typical …