In many applications, one is interested in determining which of the properties of a network
module change across conditions. For example, to validate the existence of a module, it is …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

Exhausted CD8+ T cells function poorly and are negatively regulated by inhibitory receptors.
Transcriptional profiling has identified gene expression changes associated with …

Biotic and abiotic stresses limit agricultural yields, and plants are often simultaneously
exposed to multiple stresses. Combinations of stresses such as heat and drought or cold …

Transcriptomic analyses of postmortem brains have begun to elucidate molecular
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …

To increase our understanding of psoriasis, we used high-throughput complementary DNA
sequencing (RNA-seq) to assay the transcriptomes of lesional psoriatic and normal skin. We …

Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …

Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

The merging of network theory and microarray data analysis techniques has spawned a new
field: gene coexpression network analysis. While network methods are increasingly used in …

Background The increased growth rate of young animals can lead to higher lactation
performance in adult goats; however, the effects of the ruminal microbiome on the growth of …