During human brain development, multiple signaling pathways generate diverse cell types
with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal …

Background Recent work has revealed that a core group of transcription factors (TFs)
regulates the key characteristics of embryonic stem (ES) cells: pluripotency and self …

Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Eukaryotic phytoplankton are responsible for at least 20% of annual global carbon fixation.
Their diversity and activity are shaped by interactions with prokaryotes as part of complex …

Resilience to Alzheimer's disease is an uncommon combination of high disease burden
without dementia that offers valuable insights into limiting clinical impact. Here we assessed …

Abstract Neurodevelopmental Disorders (NDDs) encompass a broad spectrum of disorders,
linked because of their origins in brain developmental processes, including diverse …

The mechanisms underlying heterosis have long remained a matter of debate, despite its
agricultural importance. How changes in transcriptional networks during plant development …

Genome-wide association studies (GWAS) have been extensively used to study common
complex diseases such as coronary artery disease (CAD), revealing 153 suggestive CAD …

Little is known about the metabolic profile of cumulus-oocyte complexes (COCs) during
maturation. The aim of this study was to determine the differential participation of enzymatic …

Genetic variation contributes to host responses and outcomes following infection by
influenza A virus or other viral infections. Yet narrow windows of disease symptoms and …