It is coming nowadays more clear that in order to obtain a unified description of the different
mechanisms governing the behavior and causality relations among the various parts of a …

It is well known that the feed-forward loops (FFLs) are typical network motifs in many real
world biological networks. The structures, functions, as well as noise characteristics of FFLs …

Much of the search for the “magic cancer bullet” or “block buster” has followed the
expectation of a single gene or protein as “the rate-limiting step” for tumor persistence …

In this review we summarize the major connections between cell growth and cell cycle in the
model eukaryote Saccharomyces cerevisiae. In S. cerevisiae regulation of cell cycle …

How many individuals are present where we see a pregnant individual? Within a substance
ontological framework, there are exactly two possible answers to this question. The standard …

Abstract Systems Biology is the science that aims to understand how biological function
absent from macromolecules in isolation, arises when they are components of their system …

Cell metabolism is the biochemical machinery that provides energy and building blocks to
sustain life. Understanding its fine regulation is of pivotal relevance in several fields, from …

Systemic approaches are needed and useful for the study of the very complex issue of
cancer. Modeling has a central position in these systemic approaches. Metabolic …

Thanks to significant improvements in LC-MS technology, metabolomics is increasingly
used as a tool to discriminate the responses of organisms to various stimuli or drugs. In this …

Background Many difficult problems in evolutionary genomics are related to mutations that
have weak effects on fitness, as the consequences of mutations with large effects are often …