Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Aspiring toward equitable benefits from genomic advances to individuals of ancestrally diverse backgrounds
Advancements in genomic technologies have shown remarkable promise for improving
health trajectories. The Human Genome Project has catalyzed the integration of genomic …
health trajectories. The Human Genome Project has catalyzed the integration of genomic …
MESuSiE enables scalable and powerful multi-ancestry fine-mapping of causal variants in genome-wide association studies
B Gao, X Zhou - Nature Genetics, 2024 - nature.com
Fine-mapping in genome-wide association studies attempts to identify causal SNPs from a
set of candidate SNPs in a local genomic region of interest and is commonly performed in …
set of candidate SNPs in a local genomic region of interest and is commonly performed in …
Shared genetic architectures of educational attainment in East Asian and European populations
Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …
ability, is associated with various health and social outcomes. Previous genome-wide …
[HTML][HTML] Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model
We introduce mvSuSiE, a multi-trait fine-mapping method for identifying putative causal
variants from genetic association data (individual-level or summary data). mvSuSiE learns …
variants from genetic association data (individual-level or summary data). mvSuSiE learns …
Genetic control of DNA methylation is largely shared across European and East Asian populations
DNA methylation is an ideal trait to study the extent of the shared genetic control across
ancestries, effectively providing hundreds of thousands of model molecular traits with large …
ancestries, effectively providing hundreds of thousands of model molecular traits with large …
Human height: a model common complex trait
M Conery, SFA Grant - Annals of human biology, 2023 - Taylor & Francis
Context Like other complex phenotypes, human height reflects a combination of
environmental and genetic factors, but is notable for being exceptionally easy to measure …
environmental and genetic factors, but is notable for being exceptionally easy to measure …
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages
The genetic influence on human vocal pitch in tonal and non-tonal languages remains
largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate …
largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate …
SharePro: an accurate and efficient genetic colocalization method accounting for multiple causal signals
Motivation Colocalization analysis is commonly used to assess whether two or more traits
share the same genetic signals identified in genome-wide association studies (GWAS), and …
share the same genetic signals identified in genome-wide association studies (GWAS), and …
Whole genome association testing in 333,100 individuals across three biobanks identifies rare non-coding single variant and genomic aggregate associations with …
The role of rare non-coding variation in complex human phenotypes is still largely unknown.
To elucidate the impact of rare variants in regulatory elements, we performed a whole …
To elucidate the impact of rare variants in regulatory elements, we performed a whole …