The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

Human breast milk is considered the optimum feeding regime for newborn infants due to its
ability to provide complete nutrition and many bioactive health factors. Breast feeding is …

Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Critical advancement is needed in the study of human milk as a biological system that
intersects and interacts with myriad internal (maternal biology) and external (diet …

The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti …

Blood vessels support tumours by providing nutrients and oxygen, while also acting as
conduits for the dissemination of cancer. Here we use mouse models of breast and lung …

Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such,
heterogeneity is one of the most important and clinically relevant areas of cancer research …

A woman has an increased risk of breast cancer if her lifelong estrogen exposure is
increased due to an early menarche, a late menopause, and/or an absence of childbearing …