[HTML][HTML] Challenges and opportunities in modelling wet granulation in pharmaceutical industry–a critical review

M Singh, S Shirazian, V Ranade, GM Walker… - Powder Technology, 2022 - Elsevier
Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms.
Wet granulation is used in pharmaceutical production to enhance formulation qualities such …

Challenges and opportunities concerning numerical solutions for population balances: a critical review

M Singh, V Ranade, O Shardt… - Journal of Physics A …, 2022 - iopscience.iop.org
Population balance models are tools for the study of dispersed systems, such as granular
materials, polymers, colloids and aerosols. They are applied with increasing frequency …

Accurate and efficient approximations for generalized population balances incorporating coagulation and fragmentation

M Singh - Journal of Computational Physics, 2021 - Elsevier
This study focuses on development of two approaches based on finite volume schemes for
solving both one-dimensional and multidimensional nonlinear simultaneous coagulation …

Analytical approach for solving population balances: a homotopy perturbation method

G Kaur, R Singh, M Singh, J Kumar… - Journal of Physics A …, 2019 - iopscience.iop.org
In the present work, a new approach is proposed for finding the analytical solution of
population balances for aggregation and fragmentation process. This approach is relying on …

Discrete finite volume approach for multidimensional agglomeration population balance equation on unstructured grid

M Singh, R Singh, S Singh, G Walker, T Matsoukas - Powder Technology, 2020 - Elsevier
In this work, a discrete finite volume scheme (FVS) is developed for approximating a
multidimensional agglomeration population balance equation on an unstructured grid …

Anomalous aggregation regimes of temperature-dependent Smoluchowski equations

AI Osinsky, NV Brilliantov - Physical Review E, 2022 - APS
Temperature-dependent Smoluchowski equations describe the ballistic agglomeration. In
contrast to the standard Smoluchowski equations for the evolution of cluster densities, with …

Characterization of simultaneous evolution of size and composition distributions using generalized aggregation population balance equation

M Singh, A Kumar, S Shirazian, V Ranade, G Walker - Pharmaceutics, 2020 - mdpi.com
The application of multi-dimensional population balance equations (PBEs) for the simulation
of granulation processes is recommended due to the multi-component system. Irrespective …

[HTML][HTML] Two-compartment modeling and dynamics of top-sprayed fluidized bed granulator

G Kaur, M Singh, T Matsoukas, J Kumar… - Applied Mathematical …, 2019 - Elsevier
Abstract A top Spray Fluidized Bed Granulator (SFBG) is being modeled and analyzed with
the help of population balance equation (PBE) and analytical as well as numerical results …

Mathematical modelling and simulation of a spray fluidized bed granulator

G Kaur, M Singh, J Kumar, T De Beer, I Nopens - Processes, 2018 - mdpi.com
In this present work, a study of the modelling and simulation for a top-sprayed fluidized bed
granulator (SFBG) is presented, which is substantially used by the pharmaceutical industry …

New discrete formulation for reduced population balance equation: an illustration to crystallization

M Singh, G Walker - Pharmaceutical Research, 2022 - Springer
In this paper, we focus on providing a discrete formulation for a reduced aggregation
population balance equation. The new formulation is simpler, easier to code, and adaptable …