Hepatic lipid metabolism is a series of complex processes that control influx and efflux of not
only hepatic lipid pools, but also organismal pools. Lipid homeostasis is usually tightly …

A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …

Metabolic reprogramming is critically involved in the development and progression of
cancer. In particular, lipid metabolism has been investigated as a source of energy, micro …

The classic toxicity of carbon tetrachloride (CCl4) is to induce liver lesion and liver fibrosis.
Liver fibrosis is a consequence of chronic liver lesion, which can progress into liver cirrhosis …

Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

Alternative mRNA splicing provides transcript diversity and may contribute to human
disease. We demonstrate that expression of several genes regulating RNA processing is …

The pregnane X receptor (PXR) is a nuclear receptor that is traditionally thought to be
specialized for sensing xenobiotic exposure. In concurrence with this feature PXR was …

Pancreatic β-cells secrete insulin in response to fluctuations in blood fuel concentrations, in
particular glucose and fatty acids. However, chronic fuel surfeit can overwhelm the …

Yeast Pah1p phosphatidate phosphatase (PAP) catalyzes the penultimate step in the
synthesis of triacylglycerol. PAP plays a crucial role in lipid homeostasis by controlling the …