The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Moving from cell monolayers to three-dimensional (3D) cultures is motivated by the need to
work with cellular models that mimic the functions of living tissues. Essential cellular …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Mammalian lungs are branched networks containing thousands to millions of airways
arrayed in intricate patterns that are crucial for respiration. How such trees are generated …

Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of …

Mammalian kidney development has helped elucidate the general concepts of
mesenchymal-epithelial interactions, inductive signaling, epithelial cell polarization, and …

Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering
what regulates such variation has been hampered by a lack of quantitative parameters …

Epithelial tubes are a fundamental tissue across the metazoan phyla and provide an
essential functional component of many of the major organs. Recent work in flies and …