Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

High-risk oncogenic human cytomegalovirus

G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the
population worldwide, usually without symptoms. The host immune response keeps the …

Modulation of innate and adaptive immunity by cytomegaloviruses

R Berry, GM Watson, S Jonjic… - Nature reviews …, 2020 - nature.com
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Genomic and geographical structure of human cytomegalovirus

OJ Charles, C Venturini, S Gantt… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (CMV) has infected humans since the origin of our species and
currently infects most of the world's population. Variability between CMV genomes is the …

[HTML][HTML] ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission

EC Semmes, IG Miller, N Rodgers, CT Phan, JH Hurst… - JCI insight, 2023 - ncbi.nlm.nih.gov
Human cytomegalovirus (HCMV) is the most common vertically transmitted infection
worldwide, yet there are no vaccines or therapeutics to prevent congenital HCMV (cCMV) …

Tumors and cytomegalovirus: An intimate interplay

G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that alternates lytic and latent infection,
infecting between 40 and 95% of the population worldwide, usually without symptoms …

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells …

R Holtappels, S Becker, S Hamdan, K Freitag… - PLoS …, 2023 - journals.plos.org
Cytomegaloviruses (CMVs) are host species-specific in their replication. It is a hallmark of all
CMVs that productive primary infection is controlled by concerted innate and adaptive …

HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation

VM Vlachava, S Seirafian, CA Fielding… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (HCMV) is a paradigm of pathogen immune evasion and sustains
lifelong persistent infection in the face of exceptionally powerful host immune responses …

Congenital cytomegalovirus infection

N Kabani, SA Ross - The Journal of infectious diseases, 2020 - academic.oup.com
Congenital cytomegalovirus (cCMV) infection is a leading cause of hearing loss and
neurological disabilities in children, with the disease burden and disabilities due to cCMV …

Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus

VM Vlahava, I Murrell, L Zhuang… - The Journal of …, 2021 - Am Soc Clin Investig
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease
following congenital infection and in immunocompromised individuals. No vaccines are …