Arsenic: signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity

Y Kumagai, D Sumi - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
Arsenic is a naturally occurring metalloid that causes oxidative stress. Exposure of humans,
experimental animals, and cultured cells to arsenic results in a variety of diverse health …

[HTML][HTML] A review of arsenic trioxide and acute promyelocytic leukemia

K Alimoghaddam - … journal of hematology-oncology and stem cell …, 2014 - ncbi.nlm.nih.gov
Arsenic Trioxide is an old drug that has recently re-introduced into new medicine. It is very
potent against a specific type of leukemic cells harboring translocation between …

[HTML][HTML] Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia

S Koka, M Xia, Y Chen, OM Bhat, X Yuan, KM Boini… - Redox Biology, 2017 - Elsevier
The NLRP3 inflammasome has been reported to be activated by atherogenic factors,
whereby endothelial injury and consequent atherosclerotic lesions are triggered in the …

Analysis of genomic dose‐response information on arsenic to inform key events in a mode of action for carcinogenicity

PR Gentry, TB McDonald, DE Sullivan… - Environmental and …, 2010 - Wiley Online Library
A comprehensive literature search was conducted to identify information on gene
expression changes following exposures to inorganic arsenic compounds. This information …

Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

M Kato, N Ohgami, S Ohnuma, K Hashimoto… - … Health and Preventive …, 2020 - Springer
Well water could be a stable source of drinking water. Recently, the use of well water as
drinking water has been encouraged in developing countries. However, many kinds of …

Roles of EGFR, PI3K, AKT, and mTOR in heavy metal-induced cancer

RL Carpenter, BH Jiang - Current cancer drug targets, 2013 - ingentaconnect.com
Humans are exposed to heavy metals through a variety of occupational and non-
occupational means. Growing evidence has accumulated that prolonged exposure to these …

Redox control of catalytic activities of membrane-associated protein tyrosine kinases

I Nakashima, K Takeda, Y Kawamoto, Y Okuno… - Archives of biochemistry …, 2005 - Elsevier
Protein tyrosine kinases (PTKs) play key roles in starting the signal transduction network for
cellular development and functions. A number of both receptor-type and non-receptor-type …

Qualitative and quantitative analysis of ROS-mediated oridonin-induced oesophageal cancer KYSE-150 cell apoptosis by atomic force microscopy

J Pi, H Cai, H Jin, F Yang, J Jiang, A Wu, H Zhu, J Liu… - PLoS …, 2015 - journals.plos.org
High levels of intracellular reactive oxygen species (ROS) in cells is recognized as one of
the major causes of cancer cell apoptosis and has been developed into a promising …

Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes

B Bang, R Gniadecki… - Experimental dermatology, 2005 - Wiley Online Library
Lipid rafts are cholesterol‐enriched microdomains in plasma membranes. The functional
activity of many membrane proteins, including death and growth factor receptors, depends …

[PDF][PDF] Ethanol induces oxidative stress in primary rat hepatocytes through the early involvement of lipid raft clustering

P Nourissat, M Travert, M Chevanne, X Tekpli… - …, 2008 - Wiley Online Library
The role of the hepatocyte plasma membrane structure in the development of oxidative
stress during alcoholic liver diseases is not yet fully understood. Previously, we have …