[HTML][HTML] Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders
MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …
The neuroimmunology of chronic pain: from rodents to humans
Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-
surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains …
surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains …
Neurobiology of cannabinoid receptor signaling
B Lutz - Dialogues in clinical neuroscience, 2020 - Taylor & Francis
The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …
system. Despite its widespread localization, its functions within the context of distinct neural …
[HTML][HTML] Role of cannabidiol in the therapeutic intervention for substance use disorders
F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2021 - frontiersin.org
Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …
Inflammation and nitro-oxidative stress as drivers of endocannabinoid system aberrations in mood disorders and schizophrenia
The endocannabinoid system (ECS) is composed of the endocannabinoid ligands
anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors …
anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors …
[HTML][HTML] Cannabinoid CB1 receptor involvement in the actions of CBD on anxiety and coping behaviors in mice
A Austrich-Olivares, MS García-Gutiérrez, L Illescas… - Pharmaceuticals, 2022 - mdpi.com
The anxiolytic and antidepressant properties of cannabidiol (CBD) have been evaluated in
several studies. However, the molecular mechanisms involved in these actions remain …
several studies. However, the molecular mechanisms involved in these actions remain …
Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9 …
Perinatal exposure to Δ 9-tetrahydrocannabinol (THC) affects brain development and might
increase the incidence of psychopathology later in life, which seems to be related to a …
increase the incidence of psychopathology later in life, which seems to be related to a …
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks
G Morris, K Walder, S Kloiber, P Amminger… - Pharmacological …, 2021 - Elsevier
The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
[HTML][HTML] CB2R activation regulates TFEB-mediated autophagy and affects lipid metabolism and inflammation of astrocytes in POCD
L Zhang, X Wang, W Yu, J Ying, P Fang… - Frontiers in …, 2022 - frontiersin.org
Evidence suggests that the accumulation of lipid drots (LDs) accelerates damage to
mitochondria and increases the release of inflammatory factors. These have been implicated …
mitochondria and increases the release of inflammatory factors. These have been implicated …
[HTML][HTML] Systems biology approaches to study lipidomes in health and disease
Lipids have many important biological roles, such as energy storage sources, structural
components of plasma membranes and as intermediates in metabolic and signaling …
components of plasma membranes and as intermediates in metabolic and signaling …