In the past decade, bacteria‐based cancer immunotherapy has attracted much attention in
the academic circle due to its unique mechanism and abundant applications in triggering the …

Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …

Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell
membranes. Here we report the development of a Salmonella-based intracellular delivery …

Successful treatment of cancer remains a challenge, due to the unique pathophysiology of
solid tumors, and the predictable emergence of resistance. Traditional methods for cancer …

The application of bacteria and bacteria-derived membrane vesicles (MVs) has promising
potential to make a great impact on the development of controllable targeted drug delivery …

There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

Metastasis accounts for 90% of cancer-related deaths and, currently, there are no effective
clinical therapies to block the metastatic cascade. A need to develop novel therapies …

Conventional chemotherapies have some limitations, including the lack of selectivity, high
toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress …

The clinical application of bacteria-mediated immune therapy dates back over a century ago.
In recent years, these strategies have advanced greatly with the rapid development of …

Inflammasome is an innate immune defense mechanism, but its overactivation can lead to
host death. Here, we show that cell death dictates mouse death caused by NLRC4 …