Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology
There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …
Proteomics and lipidomics in atherosclerotic cardiovascular disease risk prediction
NS Nurmohamed, JM Kraaijenhof, M Mayr… - European Heart …, 2023 - academic.oup.com
Given the limited accuracy of clinically used risk scores such as the Systematic COronary
Risk Evaluation 2 system and the Second Manifestations of ARTerial disease 2 risk scores …
Risk Evaluation 2 system and the Second Manifestations of ARTerial disease 2 risk scores …
Plasma proteomic associations with genetics and health in the UK Biobank
Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …
Organ aging signatures in the plasma proteome track health and disease
Animal studies show aging varies between individuals as well as between organs within an
individual,,–, but whether this is true in humans and its effect on age-related diseases is …
individual,,–, but whether this is true in humans and its effect on age-related diseases is …
Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation
A Mälarstig, F Grassmann, L Dahl, M Dimitriou… - Nature …, 2023 - nature.com
Biomarkers for early detection of breast cancer may complement population screening
approaches to enable earlier and more precise treatment. The blood proteome is an …
approaches to enable earlier and more precise treatment. The blood proteome is an …
The genetic regulation of protein expression in cerebrospinal fluid
Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways
for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 …
for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 …
Multi-omics approaches in psychoneuroimmunology and health research: conceptual considerations and methodological recommendations
The field of psychoneuroimmunology (PNI) has grown substantially in both relevance and
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …
Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients
E Duijvelaar, J Gisby, JE Peters, HJ Bogaard… - Nature …, 2024 - nature.com
The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …
viral cytopathic effects and a dysregulated host immune response. In critically ill patients …
[HTML][HTML] A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular …
Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers
confounding biomarker association studies of eGFR with reverse causation. To identify …
confounding biomarker association studies of eGFR with reverse causation. To identify …