Background Periradicular tissue fluid (PTF) offers a source of diagnostic, prognostic and
predictive biomarkers for endodontic disease. Aims (1) To optimize basic parameters for PTF …

A variety of commercial platforms are available for the simultaneous detection of multiple
cytokines and associated proteins, often employing Ab pairs to capture and detect target …

High-throughput proteomic analysis could offer new insights into the pathogenesis of
systemic sclerosis (SSc) and reveal non-invasive biomarkers for diagnosis and severity. This …

Proteomics offers unique insights into human biology and drug development, but few studies
have directly compared the utility of different proteomics platforms. We measured 2,168 …

Precision diabetes medicine (PDM) aims to reduce errors in prevention programmes,
diagnosis thresholds, prognosis prediction and treatment strategies. However, its …

Aims Improved identification of individuals at high risk of developing cardiovascular disease
would enable targeted interventions and potentially lead to reductions in mortality and …

Identifying mechanistic pathways that link obesity with COVID-19 severity provides targets
for interventions to reduce the high risk of severe outcomes owing to obesity. The authors of …

High-throughput proteomics allows researchers to simultaneously explore the roles of
thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic …

Background Heart failure (HF) is a prevalent clinical syndrome with diverse etiologies. It is
crucial to identify novel therapeutic targets based on underlying causes. Here, we aimed to …

By measuring protein abundance in blood using high-throughput antibody-based
techniques, a genetic map of blood proteins in humans replicates findings from much larger …