Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives

S Datta, D Aggarwal, N Sehrawat, M Yadav, V Sharma… - Phytomedicine, 2023 - Elsevier
Background: The liver is a well-known player in the metabolism and removal of drugs. Drug
metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the …

[HTML][HTML] The roles of NFR2-regulated oxidative stress and mitochondrial quality control in chronic liver diseases

JS Park, N Rustamov, YS Roh - Antioxidants, 2023 - mdpi.com
Chronic liver disease (CLD) affects a significant portion of the global population, leading to a
substantial number of deaths each year. Distinct forms like non-alcoholic fatty liver disease …

The genetic architecture of biological age in nine human organ systems

J Wen, YE Tian, I Skampardoni, Z Yang, Y Cui… - Nature Aging, 2024 - nature.com
Investigating the genetic underpinnings of human aging is essential for unraveling the
etiology of and developing actionable therapies for chronic diseases. Here, we characterize …

[HTML][HTML] Modification of starch digestibility and phenolic bioaccessibility in phenolic-rich flours by physical treatments with ferulic acid followed by vacuum oven and …

C Fiecke, SB Kalambur, A Bhaskar, MG Ferruzzi - LWT, 2024 - Elsevier
Consumer demand for healthy snack products has led to increased efforts to modify
glycemic responses of these products. The formation of starch-ferulic acid (FA) complexes …

Gossypetin prevents the progression of nonalcoholic steatohepatitis by regulating oxidative stress and AMP-activated protein kinase

E Oh, J Lee, S Cho, SW Kim, K Won, WS Shin… - Molecular …, 2023 - ASPET
Nonalcoholic steatohepatitis (NASH) is a severe liver metabolic disorder, however, there are
still no effective and safe drugs for its treatment. Previous clinical trials used various …

[HTML][HTML] Adherence to a Traditional Mexican Diet Is Associated with Lower Hepatic Steatosis in US-Born Hispanics of Mexican Descent with Overweight or Obesity

M Lopez-Pentecost, M Tamez, J Mattei, ET Jacobs… - Nutrients, 2023 - mdpi.com
Hispanics of Mexican descent have disproportionate rates of non-alcoholic fatty liver
disease (NAFLD). The purpose of this work is to investigate the association between the …

[HTML][HTML] Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort

AS Thompson, A Jennings, NP Bondonno… - Nutrition & …, 2024 - nature.com
Aim To examine the associations of a diet high in flavonoid-rich foods, as reflected by a
“Flavodiet Score”(FDS), the major individual food contributors to flavonoid intake, and …

[HTML][HTML] Exploring the effectiveness of flavone derivatives for treating liver diseases: Utilizing DFT, molecular docking, and molecular dynamics techniques

ST Quayum, NJI Esha, S Siraji, SS Al Abbad… - MethodsX, 2024 - Elsevier
In exploring nature's potential in addressing liver-related conditions, this study investigates
the therapeutic capabilities of flavonoids. Utilizing in silico methodologies, we focus on …

Effect of red wheat, aleurone, and testa layers on colon cancer biomarkers, nitrosative stress, and gut microbiome composition in rats

C Fiecke, S Simsek, AK Sharma, DD Gallaher - Food & Function, 2023 - pubs.rsc.org
We previously found greater reduction of colon cancer (CC) biomarkers for red wheat
compared to white wheat regardless of refinement state. In the present study we examined …

[HTML][HTML] The Synergistic Protective Effect of γ-Oryzanol (OZ) and N-Acetylcysteine (NAC) against Experimentally Induced NAFLD in Rats Entails Hypoglycemic …

AH Alwadani, SA Almasri, AA Aloud, NA Albadr… - Nutrients, 2022 - mdpi.com
This study estimated that the combined effect of γ-Oryzanol and N-acetylcysteine (NAC)
against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats also …