IgA vasculitis

E Pillebout, C Sunderkötter - Seminars in immunopathology, 2021 - Springer
IgA vasculitis (IgAV) is an inflammation of small vessels caused by perivascular deposition
of IgA and activation of neutrophils. It may present as systemic vasculitis (IgAV-Henoch …

[HTML][HTML] Focus on the gut–kidney axis in health and disease

E Stavropoulou, K Kantartzi, C Tsigalou… - Frontiers in …, 2021 - frontiersin.org
The recent new developments in technology with culture-independent techniques including
genome sequencing methodologies shed light on the identification of microbiota bacterial …

Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial

R Lafayette, J Kristensen, A Stone, J Floege, V Tesař… - The Lancet, 2023 - thelancet.com
Background IgA nephropathy is a chronic immune-mediated kidney disease and a major
cause of kidney failure worldwide. The gut mucosal immune system is implicated in its …

[PDF][PDF] Link between gut microbiota dysbiosis and chronic kidney disease.

A Noce, M Marchetti, G Marrone… - European Review for …, 2022 - europeanreview.org
During chronic kidney disease (CKD), typical alterations in the gut microbiota are observed.
The kidney no longer plays the role of the main excretory organ as this function is performed …

[HTML][HTML] Intestinal permeability and IgA provoke immune vasculitis linked to cardiovascular inflammation

MN Rivas, D Wakita, MK Franklin, TT Carvalho… - Immunity, 2019 - cell.com
Recent experimental data and clinical, genetic, and transcriptome evidence from patients
converge to suggest a key role of interleukin-1β (IL-1β) in the pathogenesis of Kawasaki …

[HTML][HTML] Probiotics ameliorate IgA nephropathy by improving gut dysbiosis and blunting NLRP3 signaling

J Tan, L Dong, Z Jiang, L Tan, X Luo, G Pei… - Journal of Translational …, 2022 - Springer
Background Recently, a few studies have indicated a relationship between the gut
microbiota and IgA nephropathy (IgAN). Whether the gut microbiota participates in the …

[HTML][HTML] IgA nephropathy: current understanding and perspectives on pathogenesis and targeted treatment

Y Du, T Cheng, C Liu, T Zhu, C Guo, S Li, X Rao, J Li - Diagnostics, 2023 - mdpi.com
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide, with varied clinical and histopathological features between individuals …

[HTML][HTML] A comparative study of the gut microbiota associated with immunoglobulin a nephropathy and membranous nephropathy

R Dong, M Bai, J Zhao, D Wang, X Ning… - Frontiers in cellular and …, 2020 - frontiersin.org
The pathogenesis of immunoglobulin A nephropathy (IgAN) and membranous nephropathy
(MN) is characterized by immune dysregulation, which is related to gut dysbiosis. The aim of …

[HTML][HTML] An update on targeted treatment of IgA nephropathy: an autoimmune perspective

X Huang, G Xu - Frontiers in pharmacology, 2021 - frontiersin.org
Immunoglobulin (Ig) A nephropathy (IgAN) is the commonest form of primary
glomerulonephritis worldwide and is, considered a significant cause of end-stage renal …

Inflammatory bowel disease is more common in patients with IgA nephropathy and predicts progression of ESKD: a Swedish population-based cohort study

J Rehnberg, A Symreng, JF Ludvigsson… - Journal of the …, 2021 - journals.lww.com
Background Case reports suggest an association between inflammatory bowel disease, a
chronic autoimmune condition linked to increased circulating IgA levels, and IgA …