[HTML][HTML] Molecular Modeling of Viral Type I Fusion Proteins: Inhibitors of Influenza Virus Hemagglutinin and the Spike Protein of Coronavirus

SS Borisevich, VV Zarubaev, DN Shcherbakov… - Viruses, 2023 - mdpi.com
The fusion of viral and cell membranes is one of the basic processes in the life cycles of
viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell …

[HTML][HTML] (+)-Usnic acid and its derivatives as inhibitors of a wide spectrum of SARS-CoV-2 viruses

AS Filimonov, OI Yarovaya, AV Zaykovskaya… - Viruses, 2022 - mdpi.com
In order to test the antiviral activity, a series of usnic acid derivatives were synthesized,
including new, previously undescribed compounds. The activity of the derivatives against …

Characterizing the structural and physicochemical properties of medicinal plants as a proposal for treating of viral malady

F Mollaamin - Trends in Immunotherapy, 2023 - systems.enpress-publisher.com
Abstract Regarding coronavirus disease (COVID-19) pandemic, this research article wants
to study some herbals as the probable therapy for this disease. Cinnamon leaves, curcuma …

Usnic acid based thiazole-hydrazones as multi-targeting inhibitors of a wide spectrum of SARS-CoV-2 viruses

OI Yarovaya, AS Filimonov, DS Baev… - New Journal of …, 2023 - pubs.rsc.org
Although the Covid-19 pandemic is officially over and the spread of coronavirus infection is
no longer considered an international emergency, the virus continues to persist in the …

Evaluation of A-ring hydroxymethylene-amino-triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1

O Kazakova, X Ma, E Tretyakova, I Smirnova… - The Journal of …, 2024 - nature.com
A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their
antiviral activity was studied. The synthesized compounds were tested for their potential …

Design, synthesis and antiviral evaluation of novel conjugates of the 1, 7, 7‐trimethylbicyclo [2.2. 1] heptane scaffold and saturated N‐heterocycles via 1, 2, 3‐triazole …

AS Sokolova, OI Yarovaya, OI Artyushin… - Archiv der …, 2024 - Wiley Online Library
A new series of heterocyclic derivatives with a 1, 7, 7‐trimethylbicyclo [2.2. 1] heptane
fragment was designed, synthesised and biologically evaluated. Synthesis of the target …

[HTML][HTML] Discovery of N-Containing (-)-Borneol Esters as Respiratory syncytial virus fusion inhibitors

AS Sokolova, OI Yarovaya, LV Kuzminykh, AA Shtro… - Pharmaceuticals, 2022 - mdpi.com
Respiratory syncytial virus (RSV) causes acute respiratory infections, thus, posing a serious
threat to the health of infants, children, and elderly people. In this study, we have discovered …

[HTML][HTML] Structural and Functional Characterization of Medicinal Plants as Selective Antibodies towards Therapy of COVID-19 Symptoms

F Mollaamin - Antibodies, 2024 - mdpi.com
Considering the COVID-19 pandemic, this research aims to investigate some herbs as
probable therapies for this disease. Achillea millefolium (Yarrow), Alkanet, Rumex patientia …

Facile Stereoselective Synthesis and Structural Study of Camphor‐and Fenchone‐Based Spirocyclic 1, 3, 4‐Oxadiazolines

KS Kovaleva, VS Abdrakhmanova… - European Journal of …, 2023 - Wiley Online Library
For the first time, an effective method for the synthesis of spirocyclic camphor‐and fenchone‐
based 1, 3, 4‐oxadiazolines has been developed. The influence of the molecular structure of …

[HTML][HTML] The Potential of Usnic-Acid-Based Thiazolo-Thiophenes as Inhibitors of the Main Protease of SARS-CoV-2 Viruses

OI Yarovaya, AS Filimonov, DS Baev, SS Borisevich… - Viruses, 2024 - mdpi.com
Although the COVID-19 pandemic caused by SARS-CoV-2 viruses is officially over, the
search for new effective agents with activity against a wide range of coronaviruses is still an …