Major contributions to and confirmations of osteoclast biology have been made by
experimental investigations of the osteopetrotic mutations in mammals. Congenital …

One of the osteopetrotic mutations in the rat, incisors‐absent (ia), exhibits generalized
skeletal sclerosis and failure or delay of tooth eruption, characteristics of other osteopetrotic …

The osteopetrotic, microphthalmic (mi/mi) mouse lacks functional osteoclasts and has also
been reported to be deficient in mast cells and natural‐killer (NK) cells. The later …

The toothless (tl/tl) mutation in the rat results in a paucity of osteoclasts and osteopetrosis
that cannot be corrected by bone marrow transplantation. In the present study we …

Osteopetrosis, a metabolic bone disease characterized by a generalized sclerosis of the
skeleton, is inherited as an autosomal recessive in a number of mammalian species. The …

Osteopetrosis is a group of metabolic bone diseases characterized by reductions in
osteoclast development and/or function. These aspects of osteoclast biology are known to …

Toothless (tl), one of four osteopetrotic mutations in the rat, is characterized by few
osteoclasts, undetectable bone resorption, and failure of correction by bone marrow …

The toothless (tl) rat is a nonlethal osteopetrotic mutation characterized by the presence of
few osteoclasts and the failure to be cured by bone‐marrow transplantation. We examined …

The osteosclerotic mouse is a new, lethal recessive skeletal mutation which inherits
osteopetrosis as an autosomal recessive. Affected mice are hypocalcemic and also have …

Osteopetrosis is a metabolic bone disease characterized by reduced bone resorption. From
experimental studies of various osteopetrotic mutations has emerged the hypothesis that …