The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Coronary microvascular disease (CMD), which affects the arterioles and capillary
endothelium that regulate myocardial perfusion, is an increasingly recognized source of …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Arterial stiffness is an age-related disorder. In the medial layer of arteries, mechanical
fracture due to fatigue failure for the pulsatile wall strain causes medial degeneration …

Understanding the causal role of the immune and inflammatory responses in hypertension
has led to questions regarding the links between hypertension and autoimmunity. Immune …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

Obesity has reached epidemic proportions and its prevalence is climbing. Obesity is
characterized by hypertrophied adipocytes with a dysregulated adipokine secretion profile …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …