[HTML][HTML] Immunopathology of RSV: an updated review
HC Bergeron, RA Tripp - Viruses, 2021 - mdpi.com
RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …
Roles and effects of interferon lambda signaling in the context of bacterial infections
DK Johnson, N Carbonetti - Journal of Interferon & Cytokine …, 2023 - liebertpub.com
Type III interferon, or interferon lambda (IFNλ), was discovered 20 years ago and has been
studied primarily for its role in combatting viral infections. However, it is also induced in …
studied primarily for its role in combatting viral infections. However, it is also induced in …
Respiratory syncytial virus protects bystander cells against influenza A virus infection by triggering secretion of type I and type III Interferons
M Czerkies, M Kochańczyk, Z Korwek, W Prus… - Journal of …, 2022 - Am Soc Microbiol
We observed the interference between two prevalent respiratory viruses, respiratory
syncytial virus (RSV) and influenza A virus (IAV)(H1N1), and characterized its molecular …
syncytial virus (RSV) and influenza A virus (IAV)(H1N1), and characterized its molecular …
[HTML][HTML] Interferon lambda signaling in macrophages is necessary for the antiviral response to influenza
RK Mallampalli, J Adair, A Elhance, D Farkas… - Frontiers in …, 2021 - frontiersin.org
Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in
murine models, yet little is known about its molecular regulation and its cognate receptor …
murine models, yet little is known about its molecular regulation and its cognate receptor …
Dual oxidase 1 promotes antiviral innate immunity
D Sarr, AD Gingerich, NM Asthiwi… - Proceedings of the …, 2021 - National Acad Sciences
Dual oxidase 1 (DUOX1) is an NADPH oxidase that is highly expre-ssed in respiratory
epithelial cells and produces H2O2 in the airway lumen. While a line of prior in vitro …
epithelial cells and produces H2O2 in the airway lumen. While a line of prior in vitro …
Bioconjugation strategies and clinical implications of Interferon-bioconjugates
Interferons (IFN) are immunomodulating, antiviral and antiproliferative cytokines for
treatment of multiple indications, including cancer, hepatitis, and autoimmune disease. The …
treatment of multiple indications, including cancer, hepatitis, and autoimmune disease. The …
Inflammatory and antiviral responses to influenza A virus infection are dysregulated in pregnant mice with allergic airway disease
Influenza A virus (IAV) infections are increased during pregnancy especially with asthma as
a comorbidity, leading to asthma exacerbations, secondary bacterial infections, intensive …
a comorbidity, leading to asthma exacerbations, secondary bacterial infections, intensive …
[HTML][HTML] Multidistrict Host–Pathogen Interaction during COVID-19 and the Development Post-Infection chronic inflammation
M Fanelli, V Petrone, M Buonifacio, E Delibato… - Pathogens, 2022 - mdpi.com
Due to the presence of the ACE2 receptor in different tissues (nasopharynx, lung, nervous
tissue, intestine, liver), the COVID-19 disease involves several organs in our bodies. SARS …
tissue, intestine, liver), the COVID-19 disease involves several organs in our bodies. SARS …
[HTML][HTML] The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis
AA Sattar, A Qaiser, H Kausar, S Aqil… - Frontiers in …, 2024 - frontiersin.org
Many studies have investigated the antiviral activity of cytokines, including interleukin-6 (IL-
6), interleukin-22 (IL-22), interleukin-32 gamma (IL-32γ), and interferon-lambda (IFN-λ) in …
6), interleukin-22 (IL-22), interleukin-32 gamma (IL-32γ), and interferon-lambda (IFN-λ) in …
IFN-λ drives distinct lung immune landscape changes and antiviral responses in human metapneumovirus infection
J Sojati, OB Parks, Y Zhang, S Walters, J Lan… - Mbio, 2024 - Am Soc Microbiol
Human metapneumovirus (HMPV) is a primary cause of acute respiratory infection, yet there
are no approved vaccines or antiviral therapies for HMPV. Early host responses to HMPV …
are no approved vaccines or antiviral therapies for HMPV. Early host responses to HMPV …