Engineering polyphenol-based polymeric nanoparticles for drug delivery and bioimaging

X Wang, Y Fan, J Yan, M Yang - Chemical Engineering Journal, 2022 - Elsevier
Polyphenols are compounds with phenolic hydroxyl groups that are widely found in natural
plants. The beneficial effects of polyphenols have been studied extensively, especially anti …

[HTML][HTML] Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections

HA Parray, S Shukla, R Perween, R Khatri… - Applied Microbiology …, 2021 - Springer
The route of administration of a therapeutic agent has a substantial impact on its success.
Therapeutic antibodies are usually administered systemically, either directly by intravenous …

[HTML][HTML] A humanized mouse model of chronic COVID-19

E Sefik, B Israelow, H Mirza, J Zhao, R Qu, E Kaffe… - Nature …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease that can present as
an uncontrolled, hyperactive immune response, causing severe immunological injury …

[HTML][HTML] Inhalable neutralizing antibodies–promising approach to combating respiratory viral infections

MYT Chow, HW Pan, HC Seow, JKW Lam - Trends in pharmacological …, 2023 - cell.com
Monoclonal antibodies represent an exciting class of therapeutics against respiratory viral
infections. Notwithstanding their specificity and affinity, the conventional parenteral …

[HTML][HTML] Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

S Halwe, A Kupke, K Vanshylla, F Liberta, H Gruell… - Viruses, 2021 - mdpi.com
Despite the recent availability of vaccines against severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2), there is an urgent need for specific anti-SARS-CoV-2 …

[HTML][HTML] Alternative routes of administration for therapeutic antibodies—state of the art

A Pitiot, N Heuzé-Vourc'h, T Sécher - Antibodies, 2022 - mdpi.com
Background: For the past two decades, there has been a huge expansion in the
development of therapeutic antibodies, with 6 to 10 novel entities approved each year …

Novel formulations and drug delivery systems to administer biological solids

Y Zhang, DA Davis, K AboulFotouh, J Wang… - Advanced drug delivery …, 2021 - Elsevier
Recent advances in formulation sciences have expanded the previously limited design
space for biological modalities, including peptide, protein, and vaccine products. At the …

[HTML][HTML] Coronavirus disease 2019: clinics, treatment, and prevention

FR Burkert, L Lanser, R Bellmann-Weiler… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic, caused by a novel severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), emerged at the end of 2019 in China …

Recent advances in respiratory immunization: a focus on COVID-19 vaccines

X He, X Chen, H Wang, G Du, X Sun - Journal of Controlled Release, 2023 - Elsevier
The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …

Delivering monoclonal antibodies via inhalation: a systematic review of clinical trials in asthma and COPD

R Laitano, L Calzetta, F Cavalli, M Cazzola… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Advances in understanding the pathophysiology of asthma and chronic
obstructive pulmonary disease (COPD) led to investigation of biologic drugs targeting …