[HTML][HTML] Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal Transduction and Targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

[HTML][HTML] Oxidative stress and hyper-inflammation as major drivers of severe COVID-19 and long COVID: implications for the benefit of high-dose intravenous vitamin C

C Vollbracht, K Kraft - Frontiers in Pharmacology, 2022 - frontiersin.org
Oxidative stress is a pivotal point in the pathophysiology of COVID-19 and presumably also
in Long-COVID. Inflammation and oxidative stress are mutually reinforcing each other, thus …

[HTML][HTML] Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof …

HK Al-Hakeim, HT Al-Rubaye, DS Al-Hadrawi… - Molecular …, 2023 - nature.com
The immune-inflammatory response during the acute phase of COVID-19, as assessed
using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the …

[HTML][HTML] Feasibility of vitamin C in the treatment of post viral fatigue with focus on long COVID, based on a systematic review of IV vitamin C on fatigue

C Vollbracht, K Kraft - Nutrients, 2021 - mdpi.com
Fatigue is common not only in cancer patients but also after viral and other infections.
Effective treatment options are still very rare. Therefore, the present knowledge on the …

[HTML][HTML] COVID-19 and selenium deficiency: a systematic review

M Fakhrolmobasheri, S Mazaheri-Tehrani… - … Trace Element Research, 2022 - Springer
Several studies have indicated that selenium deficiency may be detrimental in the context of
various viral disorders, and in the case of COVID-19, several studies have reported …

SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …

[HTML][HTML] Relation of serum copper status to survival in COVID-19

J Hackler, RA Heller, Q Sun, M Schwarzer, J Diegmann… - Nutrients, 2021 - mdpi.com
The trace element copper (Cu) is part of our nutrition and essentially needed for several
cuproenzymes that control redox status and support the immune system. In blood, the …

[HTML][HTML] Lipid peroxidation as a hallmark of severity in COVID-19 patients

M Martín-Fernández, R Aller, M Heredia-Rodríguez… - Redox Biology, 2021 - Elsevier
Background Oxidative stress may be a key player in COVID-19 pathogenesis due to its
significant role in response to infections. A defective redox balance has been related to viral …

[HTML][HTML] Biomarkers of post-COVID depression

P Lorkiewicz, N Waszkiewicz - Journal of Clinical medicine, 2021 - mdpi.com
The COVID-19 pandemic is spreading around the world and 187 million people have
already been affected. One of its after-effects is post-COVID depression, which, according to …

SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells

K Meyer, T Patra, Vijayamahantesh, R Ray - Journal of virology, 2021 - Am Soc Microbiol
Increased mortality in COVID-19 cases is often associated with microvascular complications.
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …