Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

Hepatocellular carcinoma (HCC) is one of the most deadly malignant cancers worldwide.
Research into the crucial genes responsible for maintaining the aggressive behaviour of …

The human ubiquitin proteasome system, composed of over 700 ubiquitin ligases (E3s) and
deubiquitinases (DUBs), has been difficult to characterize systematically and phenotypically …

Inflammation is essential for healthy immune function, wound healing, and resolution of
infection. RIG-I is a key RNA sensor that initiates an immune response, with activation and …

Ubiquitin chains linked through lysine63 (K63) play a critical role in inflammatory signalling.
Following ligand engagement of immune receptors, the RING E3 ligase TRAF6 builds K63 …

Congenital human cytomegalovirus (HCMV) infection is the leading cause of neurological
disabilities in children worldwide, but the mechanisms underlying these disorders are far …

A key signalling pathway required for clearance of viruses from host cells relies on the
receptor protein, retinoic acid‐inducible gene I (RIG‐I). The activity of RIG‐I is tightly …

The MID1 TRIM protein is important for ventral midline development in vertebrates, and
mutations of its B-box1 domain result in several birth defects. The B-box1 domain of the …

Novel strategies to target Trypanosoma brucei, Trypanosoma cruzi and Leishmania are
urgently needed to generate better and safer drugs against Human African …

Despite the concurrence of histidine and cysteine in the active sites of proteins associated
with Zn2+, Cd2+ and Hg2+, coordination studies of these metal ions with chelating ligands …