Background Taste disorders in general, and dysgeusia in particular, are relatively common
disorders that may be a sign of a more complex acute or chronic medical condition. During …

It has recently been shown that taste receptors, in addition to being present in the oral cavity,
exist in various extra-oral organs and tissues such as the thyroid, lungs, skin, stomach …

Sustained and non-resolved inflammation is a characteristic of periodontitis. Upon acute
inflammation, gingival fibroblasts release cytokines to recruit immune cells to counter …

Extra-virgin olive oil (EVOO) is a critical component of the Mediterranean diet, which has
been found beneficial to human health. Bitterness is often positively associated with the …

Drug development is a long, expensive and multistage process geared to achieving safe
drugs with high efficacy. A crucial prerequisite for completing the medication regimen for oral …

The human GPCR family comprises circa 800 members, activated by hundreds of thousands
of compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily …

The ectopic co-expression of taste and olfactory receptors in cardiomyocytes provides not
only possibilities for the construction of biomimetic gustatory and olfactory sensors but also …

Compounds that confer a bitter taste on fruits and vegetables (FAVs) play crucial roles in
both plant defense and health promotion. This review details the current knowledge of the …

Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …

Bitter taste receptors are involved not only in taste perception but in various physiological
functions as their anatomical location is not restricted to the gustatory system. We previously …