[HTML][HTML] The role of Interleukin 6 inhibitors in therapy of severe COVID-19

E Nasonov, M Samsonov - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cytokine storm syndrome (CSS) is a severe complication of inflammatory immune diseases
or treatment of malignancies; it may also appear during the progression of COVID-19. CSS …

The looming effects of estrogen in Covid-19: a rocky rollout

HM Al-Kuraishy, AI Al-Gareeb, H Faidah… - Frontiers in …, 2021 - frontiersin.org
In the face of the Covid-19 pandemic, an intensive number of studies have been performed
to understand in a deeper way the mechanisms behind better or worse clinical outcomes …

Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm

A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic …

Excessive matrix metalloproteinase-1 and hyperactivation of endothelial cells occurred in COVID-19 patients and were associated with the severity of COVID-19

F Syed, W Li, RF Relich, PM Russell… - The Journal of …, 2021 - academic.oup.com
Background Systemic vascular injury occurs in coronavirus disease 2019 (COVID-19)
patients; however, the underlying mechanisms remain unknown. Methods To clarify the role …

Potential role of interferons in treating COVID-19 patients

MH Abdolvahab, S Moradi-Kalbolandi, M Zarei… - International …, 2021 - Elsevier
The recently public health crises in the world is emerged by spreading the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) also named COVID-19. The virus is …

Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases

Y Gu, J Yang, C He, T Zhao, R Lu, J Liu, X Mo… - … and Targeted Therapy, 2023 - nature.com
Abstract mRNA vaccines have emerged rapidly in recent years as a prophylactic and
therapeutic agent against various diseases including cancer and infectious diseases …

Dysregulated immune responses in SARS-CoV-2-infected patients: a comprehensive overview

I Kudryavtsev, A Rubinstein, A Golovkin, O Kalinina… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in
humans more than two years ago and caused an unprecedented socio-economic burden on …

The Role of Inflammatory Cytokines (Interleukin-1 and Interleukin-6) as a Potential Biomarker in the Different Stages of COVID-19 (Mild, Severe, and Critical)

M Ghofrani Nezhad, G Jami, O Kooshkaki… - Journal of Interferon & …, 2023 - liebertpub.com
Cytokine storm refers to the overproduction of immune and inflammatory cells and their
proteins (cytokines)[interleukin (IL)-1 and IL-6] causing acute respiratory distress syndrome …

Broad severe acute respiratory syndrome coronavirus 2 cell tropism and immunopathology in lung tissues from fatal coronavirus disease 2019

S Ramos da Silva, E Ju, W Meng… - The Journal of …, 2021 - academic.oup.com
Abstract Background Coronavirus disease 2019 (COVID-19) patients manifest with
pulmonary symptoms reflected by diffuse alveolar damage (DAD), excessive inflammation …

An overview of the pathogenesis, transmission, diagnosis, and management of endemic human coronaviruses: a reflection on the past and present episodes and …

AJ Kayode, FO Banji-Onisile, AO Olaniran, AI Okoh - Pathogens, 2021 - mdpi.com
The outbreak of the 2019 coronavirus pandemic caught the world by surprise in late 2019
and has held it hostage for months with an increasing number of infections and deaths …