Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases
such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Microglia M1 phenotype causes HPA axis hyperactivity, neurotransmitter dysfunction, and
production of proinflammatory mediators and oxidants, which may contribute to the etiology …

Microglia are resident immune cells in the brain and play a central role in the development
and surveillance of the nervous system. Extensive gliosis is a common pathological feature …

Balancing microglia M1/M2 polarization has been shown as a prospective therapeutic
strategy for Parkinson's disease (PD). Various vital signaling pathways are likely to govern …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection, leaving the inflammation process without a proper resolution, leading to tissue …

Microglial polarization to the M1 phenotype (classically activated) or the M2 phenotype
(alternatively activated) is critical in determining the fate of immune responses in …

Pseudostellaria heterophylla, has historically been used as medicine food homology plant
for thousand years in China. Our previous studies had indicated that daily intake of …

Microglia, as one of the main types of glial cells in the central nervous system (CNS), are
widely distributed throughout the brain and spinal cord. The normal number and function of …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by complex
pathophysiological features. Amyloid plaques resulting from extracellular amyloid deposition …