Utilization of the microbiome in personalized medicine
Inter-individual human variability, driven by various genetic and environmental factors,
complicates the ability to develop effective population-based early disease detection …
complicates the ability to develop effective population-based early disease detection …
Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions
K Hashimoto - Molecular Psychiatry, 2023 - nature.com
The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …
Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies
D Seo, DM Holtzman - Experimental & Molecular Medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …
tremendous research efforts to understand this complex disease, the exact pathophysiology …
Dietary fiber and microbiota metabolite receptors enhance cognition and alleviate disease in the 5xFAD mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder with poorly understood etiology.
AD has several similarities with other “Western lifestyle” inflammatory diseases, where the …
AD has several similarities with other “Western lifestyle” inflammatory diseases, where the …
Modelling host–microbiome interactions in organ-on-a-chip platforms
The human microbiome orchestrates a variety of metabolic, immunological and regulatory
functions in health and disease. However, experimentally dissecting host–microbiome …
functions in health and disease. However, experimentally dissecting host–microbiome …
Harnessing human microbiomes for disease prediction
The human microbiome has been increasingly recognized as having potential use for
disease prediction. Predicting the risk, progression, and severity of diseases holds promise …
disease prediction. Predicting the risk, progression, and severity of diseases holds promise …
Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response
The tetracycline transactivator (tTA) system provides controllable transgene expression
through oral administration of the broad-spectrum antibiotic doxycycline. Antibiotic treatment …
through oral administration of the broad-spectrum antibiotic doxycycline. Antibiotic treatment …
Integration of polygenic and gut metagenomic risk prediction for common diseases
Multiomics has shown promise in noninvasive risk profiling and early detection of various
common diseases. In the present study, in a prospective population-based cohort with~ 18 …
common diseases. In the present study, in a prospective population-based cohort with~ 18 …
Curcumin Mitigates the High-Fat High-Sugar Diet-Induced Impairment of Spatial Memory, Hepatic Metabolism, and the Alteration of the Gut Microbiome in Alzheimer's …
The escalating prevalence of metabolic diseases and an aging demographic has been
correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to …
correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to …
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly
The immune system substantially influences age-related cognitive decline and Alzheimer's
disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic …
disease (AD) progression, affected by genetic and environmental factors. In a Mayo Clinic …