Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

K Bok, S Sitar, BS Graham, JR Mascola - Immunity, 2021 - cell.com
The development of effective vaccines to combat infectious diseases is a complex multi-year
and multi-stakeholder process. To accelerate the development of vaccines for coronavirus …

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and …

Quadrivalent influenza nanoparticle vaccines induce broad protection

S Boyoglu-Barnum, D Ellis, RA Gillespie… - Nature, 2021 - nature.com
Influenza vaccines that confer broad and durable protection against diverse viral strains
would have a major effect on global health, as they would lessen the need for annual …

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

KV Houser, GL Chen, C Carter, MC Crank… - Nature medicine, 2022 - nature.com
Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and
there remains a need for novel vaccine platforms capable of inducing broader responses …

More than a tripledemic: influenza A virus, respiratory syncytial virus, SARS-CoV-2, and human metapneumovirus in wastewater during winter 2022–2023

AB Boehm, MK Wolfe, BJ White, B Hughes… - … science & technology …, 2023 - ACS Publications
Wastewater monitoring can provide insights into respiratory disease occurrence in
communities that contribute to the wastewater system. Using daily measurements of RNA of …

Co-evolution of immunity and seasonal influenza viruses

AX Han, SPJ de Jong, CA Russell - Nature Reviews Microbiology, 2023 - nature.com
Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults

AT Widge, AR Hofstetter, KV Houser, SF Awan… - Science translational …, 2023 - science.org
Influenza vaccines could be improved by platforms inducing cross-reactive immunity.
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …

[HTML][HTML] Controlling timing and location in vaccines

DJ Irvine, A Aung, M Silva - Advanced Drug Delivery Reviews, 2020 - Elsevier
Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and …

P Huang, L Sun, J Li, Q Wu, N Rezaei, S Jiang, C Pan - Cell discovery, 2023 - nature.com
In recent years, highly pathogenic avian influenza H5 subtype (HPAI H5) viruses have been
prevalent around the world in both avian and mammalian species, causing serious …