TLRs: innate immune sentries against SARS-CoV-2 infection

S Mantovani, B Oliviero, S Varchetta, A Renieri… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …

SARS-CoV-2 immunity in animal models

Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …

NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins

I Tsukalov, I Sánchez-Cerrillo, O Rajas… - Nature …, 2024 - nature.com
Increased recruitment of transitional and non-classical monocytes in the lung during SARS-
CoV-2 infection is associated with COVID-19 severity. However, whether specific innate …

Heparin, low molecular weight heparin, and non-anticoagulant derivatives for the treatment of inflammatory lung disease

JK Shute - Pharmaceuticals, 2023 - mdpi.com
Unfractionated heparin has multiple pharmacological activities beyond anticoagulation.
These anti-inflammatory, anti-microbial, and mucoactive activities are shared in part by low …

Genetically engineered cellular nanovesicle as targeted dnase i delivery system for the clearance of neutrophil extracellular traps in acute lung injury

Y Du, Y Chen, F Li, Z Mao, Y Ding… - Advanced Science, 2023 - Wiley Online Library
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are prevalent critical
illnesses with a high mortality rate among patients in intensive care units. Neutrophil …

COVID-19 and the concept of thrombo-inflammation: Review of the relationship between immune response, endothelium and coagulation

E de Maistre, P Savard, PG Guinot - Journal of Clinical Medicine, 2023 - mdpi.com
COVID-19, caused by the SARS-CoV-2 virus, has revealed a complex interplay between
inflammation and coagulation, leading to the emergence of the concept of thrombo …

A narrative review: the role of NETs in acute respiratory distress syndrome/acute lung injury

X Zhou, J Jin, T Lv, Y Song - International Journal of Molecular Sciences, 2024 - mdpi.com
Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and
the alleviation and treatment of ARDS remains a major research focus. There are various …

Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing

Y Liu, C Xiang, Z Que, C Li, W Wang, L Yin… - Frontiers in …, 2023 - frontiersin.org
Neutrophils play a critical role in the immune response to infection and tissue injury.
However, recent studies have shown that neutrophils are a heterogeneous population with …

Роль нетоза в патогенезе иммуновоспалительных ревматических заболеваний

ЕЛ Насонов, АС Авдеева… - Научно …, 2023 - rsp.mediar-press.net
Аннотация Неконтролируемая активация нейтрофилов рассматривается как важный
механизм тромбовоспаления и фиброза при иммуновоспалительных ревматических …

Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2

F Vieceli Dalla Sega, F Fortini, D Licastro… - Inflammation …, 2024 - Springer
Background Endothelial dysfunction plays a central role in the pathophysiology of COVID-19
and is closely linked to the severity and mortality of the disease. The inflammatory response …