purpose. Zinc is an essential cofactor for normal cell function. Altered expression and
function of zinc transporters may contribute to the pathogenesis of neurodegenerative …

Transient receptor potential melastatin 7 (TRPM7) is an ion channel that mediates
monovalent cations out of cells, as well as the entry of divalent cations, such as zinc …

The mammalian CNS contains an abundance of chelatable zinc that is sequestered in the
vesicles of glutamatergic presynaptic terminals and co-released with glutamate …

Human breast tumors accumulate abnormally high levels of zinc (Zn). As a result, numerous
studies have implicated Zn hyper-accumulation in the etiology of breast cancer. Zinc …

This study investigates the effects of acute exposure to organophosphate insecticide
malathion (250mg/kg, ip) and/or ZnCl2 (5mg/kg, ip), with the following parameters: lipid …

Accumulation of transition metals has been suggested to be responsible for the deteriorated
nigrostriatal dopaminergic system in Parkinson's patients. In the present study, the …

purpose. The purpose of this study was to quantify the effect of mitomycin C on rabbit
keratocytes, with a view to determining its potential in modulating corneal stromal wound …

The ZnTs are a growing family of proteins involved in lowering or sequestration of cellular
zinc. Using fluorescent measurements of zinc transport we have addressed the mechanism …

Excessive “excitotoxic” accumulation of Ca2+ and Zn2+ within neurons contributes to
neurodegeneration in pathological conditions including ischemia. Putative early targets of …

Zn2+ has emerged as a major regulator of neuronal physiology, as well as an important
signaling agent in neural injury. The intracellular concentration of this metal is tightly …