Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory
and autoimmune conditions in children, have adverse effects on the growing skeleton. GCs …

During vertebrate embryonic development, cellular senescence occurs at multiple locations.
To date, it has been accepted that when there has been induction of senescence in an …

Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important
roles in aging and cancer biology. Because senescence is associated with increased cell …

Skin is the largest organ of the body with important protective functions, which become
compromised with time due to both intrinsic and extrinsic ageing processes. Cellular …

Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic
strategy for various age-related diseases. Most senolytics target antiapoptotic proteins …

Aging is associated with cognitive decline and accumulation of senescent cells in various
tissues and organs. Senolytic agents such as dasatinib and quercetin (D+ Q) in combination …

The desire of eternal youth seems to be as old as mankind. However, the increasing life
expectancy experienced by populations in developed countries also involves a significantly …

Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

A causal factor in mammalian aging is the accumulation of senescent cells (SnCs). SnCs
cause chronic inflammation, and removing SnCs decelerates aging in mice. Despite their …

Cytotoxic T lymphocytes (CTLs) used in immunotherapy are typically cultured under
atmospheric O 2 pressure but encounter hypoxic conditions inside tumors. Activating CTLs …