Cellular senescence is a cell cycle arrest in damaged or aged cells. Although this represents
a critical mechanism of tumor suppression, persistence of senescent cells during aging …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Increased oxidative stress is a crucial factor for the progression of cellular senescence and
aging. The present study aimed to investigate the effects of licochalcone D (Lico D) on …

The progressive accumulation of senescent cells in tissues in response to damage
importantly contributes to pathophysiological conditions such as fibrosis, diabetes, cancer …

Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to
endogenous hazard signals and metabolites in the circulatory system. The senescence and …

Cardiovascular disease (CVD) is the most common disease to increase as life expectancy
increases. Most high-profile pharmacological treatments for age-related CVD have led to …

Cells adopt a size that is optimal for their function, and pushing them beyond this limit can
cause cell aging and death by senescence or reduce proliferative potential. However, by …

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory
cytokine release in cells, caused by a variety of stresses. Recent work has convincingly …

Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-
cycle arrest, these cells remain metabolically active and their secretome—known as the …

Supplemental O2 (hyperoxia; 30–90% O2) is a necessary intervention for premature infants,
but it contributes to development of neonatal and pediatric asthma, necessitating better …