Using simulation modelling and systems science to help contain COVID‐19: A systematic review

W Zhang, S Liu, N Osgood, H Zhu… - Systems research and …, 2023 - Wiley Online Library
This study systematically reviews applications of three simulation approaches, that is,
system dynamics model (SDM), agent‐based model (ABM) and discrete event simulation …

Proteomics-based vaccine targets annotation and design of subunit and mRNA-based vaccines for Monkeypox virus (MPXV) against the recent outbreak

Y Jin, A Fayyaz, A Liaqat, A Khan, A Alshammari… - Computers in Biology …, 2023 - Elsevier
Monkeypox Virus (MPXV) is a growing public health threat with increasing cases and
fatalities globally. To date, no specific vaccine or small molecule therapeutic choices are …

Peptide vaccines in melanoma: chemical approaches towards improved immunotherapeutic efficacy

B Biri-Kovács, Z Bánóczi, A Tummalapally, I Szabó - Pharmaceutics, 2023 - mdpi.com
Cancer of the skin is by far the most common of all cancers. Although the incidence of
melanoma is relatively low among skin cancers, it can account for a high number of skin …

Designing multi-epitope mRNA construct as a universal influenza vaccine candidate for future epidemic/pandemic preparedness

N Rcheulishvili, J Mao, D Papukashvili, C Liu… - International Journal of …, 2023 - Elsevier
Despite the availability of prevention and treatment strategies and advancing immunization
approaches, the influenza virus remains a global threat that continues to plague humanity …

Immunoinformatics approach to design multi-epitope-based vaccine against machupo virus taking viral nucleocapsid as a potential candidate

M Naveed, SI Makhdoom, U Ali, K Jabeen, T Aziz… - Vaccines, 2022 - mdpi.com
The family members of Arenaviridae include members of the genus Machupo virus, which
have bi-segmented negative sense RNA inside the envelope and can be transferred to …

In-silico evaluation of adenoviral COVID-19 vaccination protocols: Assessment of immunological memory up to 6 months after the third dose

P Stolfi, F Castiglione, E Mastrostefano… - Frontiers in …, 2022 - frontiersin.org
Background The immune response to adenoviral COVID-19 vaccines is affected by the
interval between doses. The optimal interval is unknown. Aim We aim to explore in-silico the …

Immunoinformatic exploration of a multi-epitope-based peptide vaccine candidate targeting emerging variants of SARS-CoV-2

KM Kumar, Y Karthik, D Ramakrishna, S Balaji… - Frontiers in …, 2023 - frontiersin.org
Many countries around the world are facing severe challenges due to the recently emerging
variants of SARS-CoV-2. Over the last few months, scientists have been developing …

SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B. 1.1. 529) and consequences in structural and functional impact

Z Abduljaleel, S Melebari, M Athar, S Dehlawi… - Cellular …, 2023 - Elsevier
This study investigated the efficacy of existing vaccines against hospitalization and infection
due to the Omicron variant of COVID-19, particularly for those who received two doses of …

Construction and validation of a multi-epitope in silico vaccine model for lymphatic filariasis by targeting Brugia malayi: a reverse vaccinology approach

P Madanagopal, S Muthusamy, SN Pradhan… - Bulletin of the National …, 2023 - Springer
Background Lymphatic filariasis (LF), often referred to as elephantiasis, has been identified
as one of the 17 neglected tropical diseases by the World Health Organization. Currently …

A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron

I Palatnik-de-Sousa, ZS Wallace, SC Cavalcante… - Scientific reports, 2022 - nature.com
COVID-19 caused, as of September, 1rst, 2022, 599,825,400 confirmed cases, including
6,469,458 deaths. Currently used vaccines reduced severity and mortality but not virus …