Multidimensional progressive declines in the absence of standard biomarkers for
neurodegeneration are observed commonly in the development of schizophrenia, and are …

Brain aging, which involves a progressive loss of neuronal functions, has been reported to
be premature accelerated in probands affected by schizophrenia (SCZ). Evidence shows …

Extreme phenotype sequencing has led to the identification of high-impact rare genetic
variants for many complex disorders but has not been applied to studies of severe …

Importance The potential association of schizophrenia with distinct retinal changes is of
clinical interest but has been challenging to investigate because of a lack of sufficiently large …

Duration of untreated psychosis (DUP) is defined as the time from the onset of psychotic
symptoms until the first treatment. Studies have shown that longer DUP is associated with …

Neurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether
they affect all individuals uniformly. The aim of this systematic review and meta-analysis was …

Signatures of immune dysregulation as clinical biomarker for psychosis have remained
unclear. We aimed to compare the Neutrophil-to-lymphocyte ratio (NLR) of patients with …

Abstract 1st episode drug naïve patients with psychosis might be at higher risk for
cardiometabolic disturbances which could affect the different cognitive, and executive …

Objectives: Normative data are essential for neuropsychological evaluations, but they are
scarce for Mandarin-speaking populations, despite Mandarin being the language with the …

Question Does neurodegenerative disease underlie the increased rate of dementia
observed in older people with schizophrenia? Several studies have reported a higher …